It is becoming clear that the accumulation of ‘senescent cells’ that are induced by various stressors including DNA damage and show characteristics such as irreversible arrest of cell proliferation and secretion of bioactive molecule (SASP) is important for the onset and progression of aging-related diseases including cancer. On the other hand, the latest research suggests that cellular senescence causes abnormalities in the integrative systems of the body, such as metabolism, nerves, immunity, and blood vessels, and is involved in the breakdown of inter-organ communications, but our understanding of the regulatory mechanisms of aging and abnormal organ connections caused by cellular senescence remains limited. Our research unit aims to elucidate the basic principles of aging through multidisciplinary approach ranging from molecular to individual research, including epigenomics, nanobiotechnology, multi-omics, stem cell biology, metabolism, immunology, and disease biology, with cellular senescence at the core, and to develop innovative methods to extend healthy life span, such as cell rejuvenation through selective removal and epigenomic rearrangements of senescent cells. Through these research projects, we aim to develop human resources who have original research ideas based on the fusion of multiple fields and who can approach diverse issues from health, welfare, and medical care to solving socioeconomic problems and maintaining the social security system.