Research and development of novel genetically-engineered mouse models and patient-derived xenograft mouse models in cancer
Specialty：cancer cancer medical science
Keyword：cancer cancer stem cell oncogene drugs targeting cancer molecules
▲ Schematic illustration of innovative cancer model research
GEM (Genetically Engineered Mouse) is a cancer-developing mouse model by artificially introducing driver gene mutation, which induces cancer, in the mouse genome. PDX (Patient-Derived Xenograft) is a model that reproduces human cancer in the mouse body by xenografting cancer cells from human cancer tissue in an immunodeficient mouse.
Rapid development of next generation genome sequencing technology has made it possible to analyze genetic information at an ultra-high speed as well as to efficiently identify abnormal genes of cancer cells derived from cancer patients. Introducing such an abnormal gene into mice induces development of a cancer showing characteristics similar to that of the original cancer from the patient. In addition, it is now possible to generate super-immunodeficient mouse models that are xenografted with cancer tissues from cancer patients. This Research Unit aims, by generating those advanced cancer mouse models, to revolutionize basic cancer research and cancer treatment and to open up a new era where “drugs effective in model mice should be effective in cancer patients” from the current situation where “drugs effective in model mice turn out to be ineffective in cancer patients.”