Establishment of novel molecular targeted therapeutics based on functional characterization of critical factors involved in malignant progression of cancer
Specialty：tumor biology molecular biology
Keyword：cancer metastasis drug resistance signal transduction epigenetics molecular targeted therapeutics
▲ Search for molecular targets of cancer to prevent malignant progression
In recent years, a variety of molecular target drugs have been developed and contributed to cancer treatment. However, new problems such as resistance to such drugs have been reported. Identification of target molecules that control resistance against anti-cancer drugs, survival of cancer stem cells, invasiveness and metastasis will lead to development of the next generation molecular target drugs.
Metastasis, recurrence and drug resistance are most important problems of basic cancer research in order to overcome cancers. This Research Unit aims to elucidate, at a molecular level, the characteristics of cancer cells (stem cell-like characteristics, impaired signaling pathways, metabolic characteristics, tumor microenvironment, epigenetics, etc.) that induce malignant progression. We aim to develop new molecular targeted therapeutic strategies, which should be applied to clinical studies, by identifying molecular targets that could be the key for preventing malignant progression. In addition, through interdisciplinary collaborations with bioinformatics, drug discovery, metabolism, structural biology, etc., which should open up new avenues of research, we aim to promote world-leading cancer research. Moreover, young and talented researchers will be trained so that they become pioneers of new research fields with the aid of the diverse disciplines of this Research Unit and unique ideas based on its rich international experience.